2hbn: Difference between revisions

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{{Seed}}
[[Image:2hbn.png|left|200px]]


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==Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex==
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<StructureSection load='2hbn' size='340' side='right'caption='[[2hbn]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hbn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HBN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr>
{{STRUCTURE_2hbn|  PDB=2hbn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hbn OCA], [https://pdbe.org/2hbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hbn RCSB], [https://www.ebi.ac.uk/pdbsum/2hbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hbn ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been solved to 1.55 A. This G-quadruplex contains five Tl+ ions, three of which are interspersed between adjacent G-quartet planes and one in each of the two thymine loops. The structure displays a high degree of similarity to the K+ crystal structure [Haider et al. (2002), J. Mol. Biol., 320, 189-200], including the number and location of the monovalent cation binding sites. The highly isomorphic nature of the two structures, which contain such a large number of monovalent binding sites (relative to nucleic acid content), verifies the ability of Tl+ to mimic K+ in nucleic acids. Information from this report confirms and extends the assignment of 205Tl resonances from a previous report [Gill et al. (2005), J. Am. Chem. Soc., 127, 16 723-16 732] where 205Tl NMR was used to study monovalent cation binding to this G-quadruplex. The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale.


===Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex===
Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex.,Gill ML, Strobel SA, Loria JP Nucleic Acids Res. 2006;34(16):4506-14. Epub 2006 Aug 31. PMID:16945956<ref>PMID:16945956</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2hbn" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 16945956 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_16945956}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBN OCA].
[[Category: Gill ML]]
 
[[Category: Loria JP]]
==Reference==
[[Category: Strobel SA]]
Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex., Gill ML, Strobel SA, Loria JP, Nucleic Acids Res. 2006;34(16):4506-14. Epub 2006 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16945956 16945956]
[[Category: Gill, M L.]]
[[Category: Loria, J P.]]
[[Category: Strobel, S A.]]
[[Category: Deoxyribonucleic acid]]
[[Category: G-quadruplex]]
[[Category: Thallium]]
 
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Retrieved from "https://proteopedia.org/2hbn"