1xhp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1xhp.png|left|200px]]


<!--
==Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae==
The line below this paragraph, containing "STRUCTURE_1xhp", creates the "Structure Box" on the page.
<StructureSection load='1xhp' size='340' side='right'caption='[[1xhp]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1xhp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XHP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xhp OCA], [https://pdbe.org/1xhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xhp RCSB], [https://www.ebi.ac.uk/pdbsum/1xhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xhp ProSAT]</span></td></tr>
{{STRUCTURE_1xhp|  PDB=1xhp  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis of a protein-free U2-U6 complex from Saccharomyces cerevisiae. The observed folding of the U2-U6 complex is a four-helix junction, in which the catalytically important AGC triad base-pairs only within U6 and not with U2. The base-pairing of the AGC triad extends the U6 intramolecular stem-loop (U6 ISL), and the NMR structure of this extended U6 ISL reveals structural similarities with domain 5 of group II self-splicing introns. The observed conformation of the four-helix junction could be relevant to the first, but not the second, step of splicing and may help to position the U6 ISL adjacent to the 5' splice site.


===Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae===
U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction.,Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Epub 2004 Nov 14. PMID:15543154<ref>PMID:15543154</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_15543154}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1xhp" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15543154 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_15543154}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].
[[Category: Butcher SE]]
 
[[Category: Cornilescu G]]
==Reference==
[[Category: Sashital DG]]
U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction., Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE, Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Epub 2004 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15543154 15543154]
[[Category: Butcher, S E.]]
[[Category: Cornilescu, G.]]
[[Category: Sashital, D G.]]
[[Category: Internal bulge]]
[[Category: Metal binding site]]
[[Category: Penta-loop]]
[[Category: Rna stem-loop]]
[[Category: U6 rna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:04:23 2008''
Retrieved from "https://proteopedia.org/1xhp"