1xc1: Difference between revisions

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{{Seed}}
[[Image:1xc1.png|left|200px]]


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==Oxo Zirconium(IV) Cluster in the Ferric Binding Protein (FBP)==
The line below this paragraph, containing "STRUCTURE_1xc1", creates the "Structure Box" on the page.
<StructureSection load='1xc1' size='340' side='right'caption='[[1xc1]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1xc1]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XC1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xc1 OCA], [https://pdbe.org/1xc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xc1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xc1 ProSAT]</span></td></tr>
{{STRUCTURE_1xc1|  PDB=1xc1  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/FBP_NEIGO FBP_NEIGO] This protein may be a central component in the iron-acquisition system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/1xc1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xc1 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report a set of three 1.8-1.9 A resolution X-ray crystal structures of Neisseria gonorrhoeae Fbp (ferric-ion binding protein): (i) open-cleft apo-Fbp containing bound phosphate, (ii) open-cleft mono-Fe Fbp capped by nitrilotriacetate, and (iii) open-cleft trinuclear oxo-iron Fbp, the first structure of an iron-cluster adduct of a transferrin. The nine independent molecules in the unit cells provide 'snapshots' of the versatile dynamic structural roles of the conserved dityrosyl iron-binding motif (Tyr195-Tyr196) which control the capture and, possibly, processing of iron. These findings have implications for understanding bacterial iron acquisition and dissimilation, and organic/mineral interfaces.


===Oxo Zirconium(IV) Cluster in the Ferric Binding Protein (FBP)===
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.,Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:013129433<ref>PMID:013129433</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1xc1" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
1XC1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC1 OCA].
*[[Ferric-binding protein|Ferric-binding protein]]
 
== References ==
==Reference==
<references/>
Assembly of an oxo-zirconium(IV) cluster in a protein cleft., Zhong W, Alexeev D, Harvey I, Guo M, Hunter DJ, Zhu H, Campopiano DJ, Sadler PJ, Angew Chem Int Ed Engl. 2004 Nov 12;43(44):5914-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15472987 15472987]
__TOC__
 
</StructureSection>
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif., Zhu H, Alexeev D, Hunter DJ, Campopiano DJ, Sadler PJ, Biochem J. 2003 Nov 15;376(Pt 1):35-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/13129433 13129433]
[[Category: Large Structures]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Single protein]]
[[Category: Alexeev D]]
[[Category: Alexeev, D.]]
[[Category: Campopiano DJ]]
[[Category: Campopiano, D J.]]
[[Category: Guo M]]
[[Category: Guo, M.]]
[[Category: Harvey I]]
[[Category: Harvey, I.]]
[[Category: Hunter DJB]]
[[Category: Hunter, D J.B.]]
[[Category: Sadler PJ]]
[[Category: Sadler, P J.]]
[[Category: Zhong W]]
[[Category: Zhong, W.]]
[[Category: Zhu H]]
[[Category: Zhu, H.]]
[[Category: Metal-oxo cluster]]
[[Category: Periplasmic ferric binding protein]]
[[Category: Zirconium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:16:26 2008''

Latest revision as of 07:26, 13 August 2026

Oxo Zirconium(IV) Cluster in the Ferric Binding Protein (FBP)

1xc1, resolution 1.51Å

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