2uwq: Difference between revisions

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{{Seed}}
[[Image:2uwq.png|left|200px]]


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==Solution structure of ASPP2 N-terminus==
The line below this paragraph, containing "STRUCTURE_2uwq", creates the "Structure Box" on the page.
<StructureSection load='2uwq' size='340' side='right'caption='[[2uwq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2uwq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ycs|1ycs]]</div></td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwq OCA], [https://pdbe.org/2uwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwq RCSB], [https://www.ebi.ac.uk/pdbsum/2uwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwq ProSAT]</span></td></tr>
{{STRUCTURE_2uwq|  PDB=2uwq  |  SCENE=  }}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwq ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.


===SOLUTION STRUCTURE OF ASPP2 N-TERMINUS===
Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.,Tidow H, Andreeva A, Rutherford TJ, Fersht AR J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:17594908<ref>PMID:17594908</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_17594908}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2uwq" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17594908 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17594908}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Human]]
2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
[[Category: Large Structures]]
 
[[Category: Andreeva, A]]
==Reference==
[[Category: Fersht, A R]]
Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17594908 17594908]
[[Category: Rutherford, T J]]
[[Category: Homo sapiens]]
[[Category: Tidow, H]]
[[Category: Single protein]]
[[Category: Andreeva, A.]]
[[Category: Fersht, A R.]]
[[Category: Rutherford, T J.]]
[[Category: Tidow, H.]]
[[Category: Ank repeat]]
[[Category: Ank repeat]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
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[[Category: Sh3-domain]]
[[Category: Sh3-domain]]
[[Category: Ubiquitin-like]]
[[Category: Ubiquitin-like]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:22:07 2008''

Latest revision as of 14:50, 17 November 2021

Solution structure of ASPP2 N-terminus

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