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New page: left|200px<br /><applet load="1nch" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nch, resolution 2.1Å" /> '''STRUCTURAL BASIS OF C...
 
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[[Image:1nch.gif|left|200px]]<br /><applet load="1nch" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1nch, resolution 2.1&Aring;" />
'''STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS'''<br />


==Overview==
==STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS==
Crystal structures of the amino-terminal domain of N-cadherin provide a, picture at the atomic level of a specific adhesive contact between cells., A repeated set of dimer interfaces is common to the structure in three, lattices. These interactions combine to form a linear zipper of molecules, that mirrors the linear structure of the intracellular filaments with, which cadherins associate. This cell-adhesion zipper may provide a, mechanism to marshal individual molecular adhesive interactions into, strong bonds between cells.
<StructureSection load='1nch' size='340' side='right'caption='[[1nch]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1nch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nch OCA], [https://pdbe.org/1nch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nch RCSB], [https://www.ebi.ac.uk/pdbsum/1nch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nch ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CADH2_MOUSE CADH2_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.<ref>PMID:11433297</ref> <ref>PMID:17988630</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1nch_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nch ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1NCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with YB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NCH OCA].
*[[Cadherin 3D structures|Cadherin 3D structures]]
 
== References ==
==Reference==
<references/>
Structural basis of cell-cell adhesion by cadherins., Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grubel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA, Nature. 1995 Mar 23;374(6520):327-37. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7885471 7885471]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Als-Nielsen J]]
[[Category: Als-Nielsen, J.]]
[[Category: Colman DR]]
[[Category: Colman, D.R.]]
[[Category: Fannon AM]]
[[Category: Fannon, A.M.]]
[[Category: Grubel G]]
[[Category: Grubel, G.]]
[[Category: Hendrickson WA]]
[[Category: Hendrickson, W.A.]]
[[Category: Kwong PD]]
[[Category: Kwong, P.D.]]
[[Category: Legrand J-F]]
[[Category: Legrand, J.F.]]
[[Category: Lehmann MS]]
[[Category: Lehmann, M.S.]]
[[Category: Shapiro L]]
[[Category: Shapiro, L.]]
[[Category: Thompson A]]
[[Category: Thompson, A.]]
[[Category: YB]]
[[Category: cadherin]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:08:10 2007''

Latest revision as of 07:55, 14 February 2024

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

1nch, resolution 2.10Å

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