2r9x: Difference between revisions

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{{Seed}}
[[Image:2r9x.png|left|200px]]


<!--
==AmpC beta-lactamase with bound Phthalamide inhibitor==
The line below this paragraph, containing "STRUCTURE_2r9x", creates the "Structure Box" on the page.
<StructureSection load='2r9x' size='340' side='right'caption='[[2r9x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2r9x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=WH6:2-[(1R)-2-CARBOXY-1-(NAPHTHALEN-1-YLMETHYL)ETHYL]-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC+ACID'>WH6</scene></td></tr>
{{STRUCTURE_2r9x| PDB=2r9x |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9x OCA], [https://pdbe.org/2r9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9x RCSB], [https://www.ebi.ac.uk/pdbsum/2r9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9x ConSurf].
<div style="clear:both"></div>


===AmpC beta-lactamase with bound Phthalamide inhibitor===
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18333608}}, adds the Publication Abstract to the page
[[Category: Escherichia coli K-12]]
(as it appears on PubMed at http://www.pubmed.gov), where 18333608 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Babaoglu K]]
{{ABSTRACT_PUBMED_18333608}}
[[Category: Shoichet BK]]
 
==About this Structure==
2R9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9X OCA].
 
==Reference==
Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against beta-Lactamase., Babaoglu K, Simeonov A, Irwin JJ, Nelson ME, Feng B, Thomas CJ, Cancian L, Costi MP, Maltby DA, Jadhav A, Inglese J, Austin CP, Shoichet BK, J Med Chem. 2008 Mar 12;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18333608 18333608]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Babaoglu, K.]]
[[Category: Shoichet, B K.]]
[[Category: Ampc beta-lactamase]]
[[Category: Antibiotic resistance]]
[[Category: Hydrolase]]
[[Category: Periplasm]]
[[Category: Pthalamide]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:38:52 2008''

Latest revision as of 09:21, 21 February 2024

AmpC beta-lactamase with bound Phthalamide inhibitor

2r9x, resolution 1.90Å

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