1nhm: Difference between revisions
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New page: left|200px<br /><applet load="1nhm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nhm" /> '''THE STRUCTURE OF THE HMG BOX AND ITS INTERAC... |
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== | ==THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA== | ||
<StructureSection load='1nhm' size='340' side='right'caption='[[1nhm]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1nhm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NHM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nhm OCA], [https://pdbe.org/1nhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nhm RCSB], [https://www.ebi.ac.uk/pdbsum/1nhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nhm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HMGB1_CRIGR HMGB1_CRIGR] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nh/1nhm_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nhm ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[High mobility group protein|High mobility group protein]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Carillo | [[Category: Carillo MOM]] | ||
[[Category: Cary | [[Category: Cary PD]] | ||
[[Category: Crane-Robinson | [[Category: Crane-Robinson C]] | ||
[[Category: Driscoll | [[Category: Driscoll PC]] | ||
[[Category: Norman | [[Category: Norman DG]] | ||
[[Category: Read | [[Category: Read CM]] | ||
Latest revision as of 08:49, 10 April 2024
THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
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