2ong: Difference between revisions

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{{Seed}}
[[Image:2ong.png|left|200px]]


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==Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).==
The line below this paragraph, containing "STRUCTURE_2ong", creates the "Structure Box" on the page.
<StructureSection load='2ong' size='340' side='right'caption='[[2ong]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ong]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mentha_spicata Mentha spicata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=FPG:(1S)-1-[(1R)-1-FLUOROETHYL]-1,5-DIMETHYLHEXYL+TRIHYDROGEN+DIPHOSPHATE'>FPG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
{{STRUCTURE_2ong|  PDB=2ong  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ong FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ong OCA], [https://pdbe.org/2ong PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ong RCSB], [https://www.ebi.ac.uk/pdbsum/2ong PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ong ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q40322_MENSP Q40322_MENSP]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2ong_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ong ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.


===Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).===
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis.,Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193<ref>PMID:17372193</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_17372193}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2ong" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17372193 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17372193}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2ONG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mentha_spicata Mentha spicata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONG OCA].
 
==Reference==
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372193 17372193]
[[Category: Mentha spicata]]
[[Category: Mentha spicata]]
[[Category: Single protein]]
[[Category: Croteau R]]
[[Category: Croteau, R.]]
[[Category: Hyatt DC]]
[[Category: Hyatt, D C.]]
[[Category: Kang C]]
[[Category: Kang, C.]]
[[Category: Youn B]]
[[Category: Youn, B.]]
[[Category: 2 fluorogeranyl diphosphate]]
[[Category: 2-fluorolinalyl diphosphate]]
[[Category: Crystal structure]]
[[Category: Geranyl diphosphate]]
[[Category: Linalyl diphosphate]]
[[Category: Monoterpene cyclase]]
[[Category: Monoterpene synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:59:41 2008''

Latest revision as of 06:10, 1 October 2025

Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).

2ong, resolution 2.70Å

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