1r28: Difference between revisions

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{{Seed}}
[[Image:1r28.png|left|200px]]


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==Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom==
The line below this paragraph, containing "STRUCTURE_1r28", creates the "Structure Box" on the page.
<StructureSection load='1r28' size='340' side='right'caption='[[1r28]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1r28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R28 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r28 OCA], [https://pdbe.org/1r28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r28 RCSB], [https://www.ebi.ac.uk/pdbsum/1r28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r28 ProSAT]</span></td></tr>
{{STRUCTURE_1r28| PDB=1r28 |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
== Function ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r28_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r28 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom===
==See Also==
 
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 
== References ==
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<references/>
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__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 14690607 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_14690607}}
 
==Disease==
Known disease associated with this structure: Lymphoma, B-cell OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109565 109565]]
 
==About this Structure==
1R28 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R28 OCA].
 
==Reference==
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain., Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Prive GG, Mol Cell. 2003 Dec;12(6):1551-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14690607 14690607]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ahmad, K F.]]
[[Category: Ahmad KF]]
[[Category: Bouchard, D.]]
[[Category: Bouchard D]]
[[Category: Kiang, C L.]]
[[Category: Kiang CL]]
[[Category: Lax, S A.]]
[[Category: Lax SA]]
[[Category: Licht, J D.]]
[[Category: Licht JD]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: Mayer, S.]]
[[Category: Mayer S]]
[[Category: Melnick, A.]]
[[Category: Melnick A]]
[[Category: Prive, G G.]]
[[Category: Prive GG]]
[[Category: B-cell lymphoma]]
[[Category: Btb domain]]
[[Category: Transcriptional repression]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:40:44 2008''
Retrieved from "https://proteopedia.org/1r28"