2rht: Difference between revisions

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{{Seed}}
[[Image:2rht.png|left|200px]]


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==Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3-Cl HOPDA==
The line below this paragraph, containing "STRUCTURE_2rht", creates the "Structure Box" on the page.
<StructureSection load='2rht' size='340' side='right'caption='[[2rht]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paraburkholderia_xenovorans_LB400 Paraburkholderia xenovorans LB400]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RHT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1E:(2Z,4E)-3-CHLORO-2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOIC+ACID'>C1E</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
{{STRUCTURE_2rht|  PDB=2rht  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rht OCA], [https://pdbe.org/2rht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rht RCSB], [https://www.ebi.ac.uk/pdbsum/2rht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rht ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3-Cl HOPDA===
== Function ==
 
[https://www.uniprot.org/uniprot/BPHD_PARXL BPHD_PARXL] Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).<ref>PMID:16964968</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rht_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17932031}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2RHT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_xenovorans Burkholderia xenovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHT OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rht ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization., Bhowmik S, Horsman GP, Bolin JT, Eltis LD, J Biol Chem. 2007 Dec 14;282(50):36377-85. Epub 2007 Oct 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932031 17932031]
<references/>
[[Category: Burkholderia xenovorans]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Bhowmik, S.]]
[[Category: Large Structures]]
[[Category: Bolin, J T.]]
[[Category: Paraburkholderia xenovorans LB400]]
[[Category: Aromatic hydrocarbons catabolism]]
[[Category: Bhowmik S]]
[[Category: C-c bond hydrolase]]
[[Category: Bolin JT]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:09:02 2008''

Latest revision as of 09:22, 21 February 2024

Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3-Cl HOPDA

2rht, resolution 1.70Å

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