1pmc: Difference between revisions

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[[Image:1pmc.png|left|200px]]


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==PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)==
The line below this paragraph, containing "STRUCTURE_1pmc", creates the "Structure Box" on the page.
<StructureSection load='1pmc' size='340' side='right'caption='[[1pmc]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Locusta_migratoria Locusta migratoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PMC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 36 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pmc OCA], [https://pdbe.org/1pmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pmc RCSB], [https://www.ebi.ac.uk/pdbsum/1pmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pmc ProSAT]</span></td></tr>
{{STRUCTURE_1pmc|  PDB=1pmc  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/LCM_LOCMI LCM_LOCMI] Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure and the disulfide pairings of a 36-residue proteinase inhibitor isolated from the insect Locusta migratoria have been determined using NMR spectroscopy and simulated annealing calculations. The peptide, termed PMP-C, was previously shown to inhibit bovine alpha-chymotrypsin as well as human leukocyte elastase, and was also found to block high-voltage-activated Ca2+ currents in rat sensory neurones. PMP-C has a prolate ellipsoid shape and adopts a tertiary fold hitherto unobserved in the large group of small "canonical" proteinase inhibitors. The over-all fold consists mainly of three strands arranged in a right-handed twisted, antiparallel, beta-sheet that demarcates a cavity, together with a linear amino-terminal segment oriented almost perpendicular to the three strands of the beta-sheet. Inside the cavity a phenyl ring constitutes the centre of a hydrophobic core. The proteinase binding loop is located in the carboxy-terminal part of the molecule, between two cysteine residues involved in disulfide bridges. Its conformation resembles that found in other small canonical proteinase inhibitors. A comparison of PMP-C structure with the recently published solution structure of the related peptide PMP-D2 shows that the most significant differences are complementary changes involved in the stabilization of similar folds. This comparison led us to review the structure of PMP-D2 and to identify two salt bridges in PMP-D2.


===PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)===
Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors.,Mer G, Hietter H, Kellenberger C, Renatus M, Luu B, Lefevre JF J Mol Biol. 1996 Apr 26;258(1):158-71. PMID:8613985<ref>PMID:8613985</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
{{ABSTRACT_PUBMED_8613985}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1PMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Locusta_migratoria Locusta migratoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMC OCA].
 
==Reference==
Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors., Mer G, Hietter H, Kellenberger C, Renatus M, Luu B, Lefevre JF, J Mol Biol. 1996 Apr 26;258(1):158-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8613985 8613985]
[[Category: Locusta migratoria]]
[[Category: Locusta migratoria]]
[[Category: Single protein]]
[[Category: Hietter H]]
[[Category: Hietter, H.]]
[[Category: Lefevre J-F]]
[[Category: Lefevre, J F.]]
[[Category: Mer G]]
[[Category: Mer, G.]]
[[Category: Calcium channel blocker]]
 
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Retrieved from "https://proteopedia.org/1pmc"