1mxq: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1mxq.png|left|200px]]


<!--
==Solution Structure of the Tachykinin Peptide Eledoisin==
The line below this paragraph, containing "STRUCTURE_1mxq", creates the "Structure Box" on the page.
<StructureSection load='1mxq' size='340' side='right'caption='[[1mxq]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eledone_moschata Eledone moschata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MXQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
{{STRUCTURE_1mxq|  PDB=1mxq  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxq OCA], [https://pdbe.org/1mxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mxq RCSB], [https://www.ebi.ac.uk/pdbsum/1mxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mxq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TKN_ELECI TKN_ELECI] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Both the aqueous and the lipid-induced structure of eledoisin, an undecapeptide of mollusk origin, have been studied by two-dimensional proton nuclear magnetic resonance spectroscopy and distance geometry calculations. Unambiguous nuclear magnetic resonance assignments of protons have been made with the aid of correlation spectroscopy experiments and nuclear Overhauser effect spectroscopy experiments. The distance constraints obtained from the nuclear magnetic resonance data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water and dimethyl sulfoxide, eledoisin prefers to be in an extended chain conformation, whereas in the presence of perdeuterated dodecylphosphocholine micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M11) of the peptide. N terminus, though less defined, also displays some degree of order and a possible turn structure. The conformation adopted by eledoisin in the presence of dodecylphosphocholine micelles is similar to the structural motif typical of neurokinin-2 selective agonists and with that reported for kassinin in hydrophobic environment.


===Solution Structure of the Tachykinin Peptide Eledoisin===
Solution structure of the tachykinin peptide eledoisin.,Grace RC, Chandrashekar IR, Cowsik SM Biophys J. 2003 Jan;84(1):655-64. PMID:12524318<ref>PMID:12524318</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_12524318}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1mxq" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 12524318 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12524318}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Eledone moschata]]
1MXQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXQ OCA].
[[Category: Large Structures]]
 
[[Category: Chandrashekar IR]]
==Reference==
[[Category: Cowsik SM]]
Solution structure of the tachykinin peptide eledoisin., Grace RC, Chandrashekar IR, Cowsik SM, Biophys J. 2003 Jan;84(1):655-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12524318 12524318]
[[Category: Grace RC]]
[[Category: Single protein]]
[[Category: Chandrashekar, I R.]]
[[Category: Cowsik, S M.]]
[[Category: Grace, R C.]]
[[Category: 3 10 helix]]
[[Category: Dpc micelle]]
[[Category: Helix]]
[[Category: Lipid induced conformation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:10:41 2008''
Retrieved from "https://proteopedia.org/1mxq"