2elg: Difference between revisions

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{{Seed}}
[[Image:2elg.png|left|200px]]


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==The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 degree celsius==
The line below this paragraph, containing "STRUCTURE_2elg", creates the "Structure Box" on the page.
<StructureSection load='2elg' size='340' side='right'caption='[[2elg]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2elg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene></td></tr>
{{STRUCTURE_2elg|  PDB=2elg  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elg OCA], [https://pdbe.org/2elg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elg RCSB], [https://www.ebi.ac.uk/pdbsum/2elg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elg ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Several crystal structure analyses of complexes of synthetic polyamine compounds, including N(1)-(2-(2-aminoethylamino))ethyl)ethane-1,2-diamine PA(222) and N(1)-(2-(2-(2-aminoethylamino)ethylamino)ethyl)ethane-1,2-diamine PA(2222), and left-handed Z-DNA d(CGCGCG)(2) have been reported. However, until now, there have been no examples of naturally occurring polyamines bound to the minor groove of the left-handed Z-DNA of d(CGCGCG)(2) molecule. We have found that spermidine, a natural polyamine, is connected to the minor groove of left-handed Z-DNA of d(CGCGCG)(2) molecule in a crystalline complex grown at 10 degrees C. The electron density of the DNA molecule was clear enough to determine that the spermidine was connected in the minor groove of two symmetry related molecules of left-handed Z-DNA d(CGCGCG)(2). This is the first example that a spermidine molecule can form a bridge conformation between two symmetry related molecules of left-handed Z-DNA d(CGCGCG)(2) in the minor groove.


===The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 degree celsius===
The rare crystallographic structure of d(CGCGCG)(2): the natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)(2) at 10 degrees C.,Ohishi H, Tozuka Y, Da-Yang Z, Ishida T, Nakatani K Biochem Biophys Res Commun. 2007 Jun 22;358(1):24-8. Epub 2007 Apr 17. PMID:17467661<ref>PMID:17467661</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2elg" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17467661 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17467661}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
2ELG is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELG OCA].
[[Category: Large Structures]]
 
[[Category: Ishida T]]
==Reference==
[[Category: Nakatani K]]
The rare crystallographic structure of d(CGCGCG)(2): the natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)(2) at 10 degrees C., Ohishi H, Tozuka Y, Da-Yang Z, Ishida T, Nakatani K, Biochem Biophys Res Commun. 2007 Jun 22;358(1):24-8. Epub 2007 Apr 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17467661 17467661]
[[Category: Ohishi H]]
[[Category: Single protein]]
[[Category: Tozuka Y]]
[[Category: Ishida, T.]]
[[Category: Zhou DY]]
[[Category: Nakatani, K.]]
[[Category: Ohishi, H.]]
[[Category: Tozuka, Y.]]
[[Category: Zhou, D Y.]]
[[Category: Left-handed z-dna]]
[[Category: Polyamine]]
[[Category: Spermidine]]
[[Category: X-ray crystallography]]
 
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