1qwe: Difference between revisions

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{{Seed}}
[[Image:1qwe.png|left|200px]]


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==C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12==
The line below this paragraph, containing "STRUCTURE_1qwe", creates the "Structure Box" on the page.
<StructureSection load='1qwe' size='340' side='right'caption='[[1qwe]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QWE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qwe OCA], [https://pdbe.org/1qwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qwe RCSB], [https://www.ebi.ac.uk/pdbsum/1qwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qwe ProSAT]</span></td></tr>
{{STRUCTURE_1qwe|  PDB=1qwe  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRC_AVISR SRC_AVISR] This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qw/1qwe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qwe ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.


===C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12===
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.,Feng S, Kasahara C, Rickles RJ, Schreiber SL Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911<ref>PMID:8618911</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1qwe" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_8618911}}, adds the Publication Abstract to the page
*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 8618911 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_8618911}}
__TOC__
 
</StructureSection>
==About this Structure==
1QWE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWE OCA].
 
==Reference==
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8618911 8618911]
[[Category: Avian sarcoma virus]]
[[Category: Avian sarcoma virus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Transferase]]
[[Category: Chiyoshi K]]
[[Category: Chiyoshi, K.]]
[[Category: Feng S]]
[[Category: Feng, S.]]
[[Category: Rickles RJ]]
[[Category: Rickles, R J.]]
[[Category: Schreiber SL]]
[[Category: Schreiber, S L.]]
[[Category: Class ii ligand complex]]
[[Category: Src sh3 domain]]
 
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Latest revision as of 09:02, 22 May 2024

C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND APP12

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