1tdc: Difference between revisions

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{{Seed}}
[[Image:1tdc.png|left|200px]]


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==STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE==
The line below this paragraph, containing "STRUCTURE_1tdc", creates the "Structure Box" on the page.
<StructureSection load='1tdc' size='340' side='right'caption='[[1tdc]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1tdc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
{{STRUCTURE_1tdc| PDB=1tdc |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdc OCA], [https://pdbe.org/1tdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdc RCSB], [https://www.ebi.ac.uk/pdbsum/1tdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdc ConSurf].
<div style="clear:both"></div>


===STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_8343503}}, adds the Publication Abstract to the page
[[Category: Lacticaseibacillus casei]]
(as it appears on PubMed at http://www.pubmed.gov), where 8343503 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Carreras CW]]
{{ABSTRACT_PUBMED_8343503}}
[[Category: Chang LC]]
 
[[Category: Perry KM]]
==About this Structure==
[[Category: Santi DV]]
1TDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDC OCA].
[[Category: Stroud RM]]
 
==Reference==
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate., Perry KM, Carreras CW, Chang LC, Santi DV, Stroud RM, Biochemistry. 1993 Jul 20;32(28):7116-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8343503 8343503]
[[Category: Lactobacillus casei]]
[[Category: Single protein]]
[[Category: Thymidylate synthase]]
[[Category: Carreras, C W.]]
[[Category: Chang, L C.]]
[[Category: Perry, K M.]]
[[Category: Santi, D V.]]
[[Category: Stroud, R M.]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:45:36 2008''
Retrieved from "https://proteopedia.org/1tdc"