1nrl: Difference between revisions

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{{Seed}}
[[Image:1nrl.png|left|200px]]


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==Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813==
The line below this paragraph, containing "STRUCTURE_1nrl", creates the "Structure Box" on the page.
<StructureSection load='1nrl' size='340' side='right'caption='[[1nrl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nrl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NRL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRL:[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC+ACID+DIETHLYL+ESTER'>SRL</scene></td></tr>
{{STRUCTURE_1nrl| PDB=1nrl |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nrl OCA], [https://pdbe.org/1nrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nrl RCSB], [https://www.ebi.ac.uk/pdbsum/1nrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nrl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nrl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nrl ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813===
==See Also==
 
*[[Pregnane X receptor 3D structures|Pregnane X receptor 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_12909012}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 12909012 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_12909012}}
 
==About this Structure==
1NRL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRL OCA].
 
==Reference==
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor., Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR, J Mol Biol. 2003 Aug 22;331(4):815-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12909012 12909012]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Davis-Searles, P R.]]
[[Category: Davis-Searles PR]]
[[Category: Lambert, M H.]]
[[Category: Lambert MH]]
[[Category: Redinbo, M R.]]
[[Category: Redinbo MR]]
[[Category: Watkins, R E.]]
[[Category: Watkins RE]]
[[Category: Coactivator]]
[[Category: Ligand binding domain]]
[[Category: Nuclear receptor]]
[[Category: Pxr]]
[[Category: Src-1]]
[[Category: Xenobiotic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:49:37 2008''
Retrieved from "https://proteopedia.org/1nrl"