2f5t: Difference between revisions

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{{Seed}}
[[Image:2f5t.png|left|200px]]


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==Crystal Structure of the sugar binding domain of the archaeal transcriptional regulator TrmB==
The line below this paragraph, containing "STRUCTURE_2f5t", creates the "Structure Box" on the page.
<StructureSection load='2f5t' size='340' side='right'caption='[[2f5t]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
{{STRUCTURE_2f5t| PDB=2f5t |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5t OCA], [https://pdbe.org/2f5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5t RCSB], [https://www.ebi.ac.uk/pdbsum/2f5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRMBR_THELN TRMBR_THELN] Inhibits transcription of the trehalose/maltose transport gene cluster (malE operon). Acts by binding to two different operator sequences in the promoter, preventing polymerase recruitment and transcription.<ref>PMID:12426307</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5t ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the sugar binding domain of the archaeal transcriptional regulator TrmB===
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16473881}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16473881 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16473881}}
 
==About this Structure==
2F5T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5T OCA].
 
==Reference==
Crystal structure of the sugar binding domain of the archaeal transcriptional regulator TrmB., Krug M, Lee SJ, Diederichs K, Boos W, Welte W, J Biol Chem. 2006 Apr 21;281(16):10976-82. Epub 2006 Feb 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16473881 16473881]
[[Category: Single protein]]
[[Category: Thermococcus litoralis]]
[[Category: Thermococcus litoralis]]
[[Category: Boos, W.]]
[[Category: Boos W]]
[[Category: Diederichs, K.]]
[[Category: Diederichs K]]
[[Category: Krug, M.]]
[[Category: Krug M]]
[[Category: Lee, S J.]]
[[Category: Lee SJ]]
[[Category: Welte, W.]]
[[Category: Welte W]]
[[Category: Sugar-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:14:24 2008''
Retrieved from "https://proteopedia.org/2f5t"