2pid: Difference between revisions

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{{Seed}}
[[Image:2pid.png|left|200px]]


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==Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with an adenylate analog==
The line below this paragraph, containing "STRUCTURE_2pid", creates the "Structure Box" on the page.
<StructureSection load='2pid' size='340' side='right'caption='[[2pid]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PID FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YSA:5-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE'>YSA</scene></td></tr>
{{STRUCTURE_2pid| PDB=2pid |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pid OCA], [https://pdbe.org/2pid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pid RCSB], [https://www.ebi.ac.uk/pdbsum/2pid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pid ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SYYM_HUMAN SYYM_HUMAN] Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:[https://omim.org/entry/613561 613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.<ref>PMID:20598274</ref> <ref>PMID:22504945</ref>
== Function ==
[https://www.uniprot.org/uniprot/SYYM_HUMAN SYYM_HUMAN] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).<ref>PMID:15779907</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/2pid_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pid ConSurf].
<div style="clear:both"></div>


===Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with an adenylate analog===
==See Also==
 
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 17997975 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_17997975}}
 
==About this Structure==
2PID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PID OCA].
 
==Reference==
Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features., Bonnefond L, Frugier M, Touze E, Lorber B, Florentz C, Giege R, Sauter C, Rudinger-Thirion J, Structure. 2007 Nov;15(11):1505-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17997975 17997975]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Tyrosine--tRNA ligase]]
[[Category: Bonnefond L]]
[[Category: Bonnefond, L.]]
[[Category: Florentz C]]
[[Category: Florentz, C.]]
[[Category: Frugier M]]
[[Category: Frugier, M.]]
[[Category: Giege R]]
[[Category: Giege, R.]]
[[Category: Lorber B]]
[[Category: Lorber, B.]]
[[Category: Rudinger-Thirion J]]
[[Category: Rudinger-Thirion, J.]]
[[Category: Sauter C]]
[[Category: Sauter, C.]]
[[Category: Touze E]]
[[Category: Touze, E.]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Atp-binding]]
[[Category: Ligase]]
[[Category: Mitochondrion]]
[[Category: Nucleotide-binding]]
[[Category: Protein biosynthesis]]
[[Category: Protein-substrate complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:23:52 2008''
Retrieved from "https://proteopedia.org/2pid"