2jja: Difference between revisions

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{{Seed}}
[[Image:2jja.png|left|200px]]


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==Crystal structure of GNA with synthetic copper base pair==
The line below this paragraph, containing "STRUCTURE_2jja", creates the "Structure Box" on the page.
<StructureSection load='2jja' size='340' side='right'caption='[[2jja]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=ZAD:(S)-1-(2,3-DIHYDROXYPROPYL)-ADENINE'>ZAD</scene>, <scene name='pdbligand=ZCY:(S)-1-(2,3-DIHYDROXYPROPYL)-CYTOSINE'>ZCY</scene>, <scene name='pdbligand=ZGU:(S)-1-(2,3-DIHYDROXYPROPYL)-GUANINE'>ZGU</scene>, <scene name='pdbligand=ZHP:(S)-1-(2,3-DIHYDROXYPROPYL)-HYDROXYPYRIDONE'>ZHP</scene>, <scene name='pdbligand=ZTH:(S)-1-(2,3-DIHYDROXYPROPYL)-THYMINE'>ZTH</scene></td></tr>
{{STRUCTURE_2jja|  PDB=2jja  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jja OCA], [https://pdbe.org/2jja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jja RCSB], [https://www.ebi.ac.uk/pdbsum/2jja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jja ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of an 8-mer (S)-GNA duplex is presented. As a tool for phasing, the anomalous diffraction of two copper(II) ions within two artificial metallo-base pairs was employed. The duplex structure confirms a canonical Watson-Crick base pairing scheme of GNA with antiparallel strands. The duplex secondary structure is distinct from canonical A- and B-form nucleic acids and can be described as a right-handed helical ribbon wrapped around the helix axis, resulting in a large hollow core. Most intriguingly, neighboring base pairs slide strongly against each other, resulting in extensive interstrand base-base hydrophobic interactions along with unusual hydrophobic intrastrand interactions of nucleobases with their backbone. These results reveal how a minimal nucleic acid backbone can support highly stable Watson-Crick-like duplex formation.


===CRYSTAL STRUCTURE OF GNA WITH SYNTHETIC COPPER BASE PAIR===
Duplex structure of a minimal nucleic acid.,Schlegel MK, Essen LO, Meggers E J Am Chem Soc. 2008 Jul 2;130(26):8158-9. Epub 2008 Jun 5. PMID:18529005<ref>PMID:18529005</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2JJA is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJA OCA].
<div class="pdbe-citations 2jja" style="background-color:#fffaf0;"></div>
 
== References ==
==Reference==
<references/>
Duplex structure of a minimal nucleic acid., Schlegel MK, Essen LO, Meggers E, J Am Chem Soc. 2008 Jul 2;130(26):8158-9. Epub 2008 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18529005 18529005]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Essen, L O.]]
[[Category: Large Structures]]
[[Category: Meggers, E.]]
[[Category: Synthetic construct]]
[[Category: Schlegel, M K.]]
[[Category: Essen L-O]]
[[Category: Glycol nucleic acid]]
[[Category: Meggers E]]
[[Category: Gna]]
[[Category: Schlegel MK]]
[[Category: Nucleic acid]]
[[Category: Rna]]
[[Category: Synthetic base pair]]
 
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Retrieved from "https://proteopedia.org/2jja"