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New page: left|200px<br /><applet load="1odd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1odd, resolution 2.2Å" /> '''OMPR C-TERMINAL DOMAI...
 
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[[Image:1odd.jpg|left|200px]]<br /><applet load="1odd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1odd, resolution 2.2&Aring;" />
'''OMPR C-TERMINAL DOMAIN (OMPR-C) FROM ESCHERICHIA COLI'''<br />


==Overview==
==OMPR C-TERMINAL DOMAIN (OMPR-C) FROM ESCHERICHIA COLI==
The C-terminal DNA-binding domain of OmpR, a positive regulator involved, in osmoregulation expression of the ompF and ompC genes in Escherichia, coli, has a helix-turn-helix variant motif. The 'turn' region, consisting, of 11 residues, forms an RNA polymerase contact site.
<StructureSection load='1odd' size='340' side='right'caption='[[1odd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1odd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ODD FirstGlance]. <br>
1ODD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ODD OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odd OCA], [https://pdbe.org/1odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1odd RCSB], [https://www.ebi.ac.uk/pdbsum/1odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1odd ProSAT]</span></td></tr>
==Reference==
</table>
Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site., Kondo H, Nakagawa A, Nishihira J, Nishimura Y, Mizuno T, Tanaka I, Nat Struct Biol. 1997 Jan;4(1):28-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8989318 8989318]
== Function ==
[[Category: Escherichia coli]]
[https://www.uniprot.org/uniprot/OMPR_ECOLI OMPR_ECOLI] The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and ompC; its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer, it turns on the expression of the ompC gene; as a monomer, it turns on the expression of the ompF gene.
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Kondou, H.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Nakagawa, A.]]
Check<jmol>
[[Category: Tanaka, I.]]
  <jmolCheckbox>
[[Category: dna binding domain]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1odd_consurf.spt"</scriptWhenChecked>
[[Category: gene regulatory protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: positive response regulator]]
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:55:36 2007''
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1odd ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Kondou H]]
[[Category: Nakagawa A]]
[[Category: Tanaka I]]

Latest revision as of 08:01, 14 February 2024

OMPR C-TERMINAL DOMAIN (OMPR-C) FROM ESCHERICHIA COLI

1odd, resolution 2.20Å

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