1onk: Difference between revisions
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New page: left|200px<br /><applet load="1onk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1onk, resolution 2.10Å" /> '''Mistletoe lectin I f... |
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== | ==Mistletoe lectin I from viscum album== | ||
<StructureSection load='1onk' size='340' side='right'caption='[[1onk]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
[[Category: | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1onk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onk OCA], [https://pdbe.org/1onk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onk RCSB], [https://www.ebi.ac.uk/pdbsum/1onk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onk_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1onk ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Viscum album]] | [[Category: Viscum album]] | ||
[[Category: Betzel C]] | |||
[[Category: Betzel | [[Category: Gabdoulkhakov AG]] | ||
[[Category: Gabdoulkhakov | [[Category: Konareva N]] | ||
[[Category: Konareva | [[Category: Kornev AN]] | ||
[[Category: Kornev | [[Category: Kornilov V]] | ||
[[Category: Kornilov | [[Category: Krauspenhaar R]] | ||
[[Category: Krauspenhaar | [[Category: Mikhailov AM]] | ||
[[Category: Mikhailov | [[Category: Nikonov SV]] | ||
[[Category: Nikonov | [[Category: Savoshkina Y]] | ||
[[Category: Savoshkina | [[Category: Stoeva S]] | ||
[[Category: Stoeva | [[Category: Voelter W]] | ||
[[Category: Voelter | |||
Latest revision as of 07:21, 25 October 2023
Mistletoe lectin I from viscum album
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