1nwr: Difference between revisions

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{{Seed}}
[[Image:1nwr.png|left|200px]]


<!--
==Crystal structure of human cartilage gp39 (HC-gp39)==
The line below this paragraph, containing "STRUCTURE_1nwr", creates the "Structure Box" on the page.
<StructureSection load='1nwr' size='340' side='right'caption='[[1nwr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nwr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_1nwr| PDB=1nwr |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwr OCA], [https://pdbe.org/1nwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwr RCSB], [https://www.ebi.ac.uk/pdbsum/1nwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwr ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
== Function ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwr ConSurf].
<div style="clear:both"></div>


===Crystal structure of human cartilage gp39 (HC-gp39)===
==See Also==
 
*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_12851408}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 12851408 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_12851408}}
 
==About this Structure==
1NWR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA].
 
==Reference==
Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39., Fusetti F, Pijning T, Kalk KH, Bos E, Dijkstra BW, J Biol Chem. 2003 Sep 26;278(39):37753-60. Epub 2003 Jul 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12851408 12851408]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bos, E.]]
[[Category: Bos E]]
[[Category: Dijkstra, B W.]]
[[Category: Dijkstra BW]]
[[Category: Fusetti, F.]]
[[Category: Fusetti F]]
[[Category: Kalk, K H.]]
[[Category: Kalk KH]]
[[Category: Pijning, T.]]
[[Category: Pijning T]]
[[Category: Chitin]]
[[Category: Chitinase-like protein]]
[[Category: N-acetylglucosamine]]
[[Category: Rheumatoid arthritis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:51:57 2008''

Latest revision as of 08:53, 10 April 2024

Crystal structure of human cartilage gp39 (HC-gp39)

1nwr, resolution 2.70Å

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