2jpl: Difference between revisions

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{{Seed}}
[[Image:2jpl.png|left|200px]]


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==Lactococcin G-a in TFE==
The line below this paragraph, containing "STRUCTURE_2jpl", creates the "Structure Box" on the page.
<StructureSection load='2jpl' size='340' side='right'caption='[[2jpl]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jpl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JPL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpl OCA], [https://pdbe.org/2jpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpl RCSB], [https://www.ebi.ac.uk/pdbsum/2jpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpl ProSAT]</span></td></tr>
{{STRUCTURE_2jpl|  PDB=2jpl  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/LCGA_LACLL LCGA_LACLL] Kills Lactococci.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structures of the two peptides, lactococcin G-alpha (LcnG-alpha; contains 39 residues) and lactococcin G-beta (LcnG-beta, contains 35 residues), that constitute the two-peptide bacteriocin lactococcin G (LcnG) have been determined by nuclear magnetic resonance (NMR) spectroscopy in the presence of DPC micelles and TFE. In DPC, LcnG-alpha has an N-terminal alpha-helix (residues 3-21) that contains a GxxxG helix-helix interaction motif (residues 7-11) and a less well defined C-terminal alpha-helix (residues 24-34), and in between (residues 18-22) there is a second somewhat flexible GxxxG-motif. Its structure in TFE was similar. In DPC, LcnG-beta has an N-terminal alpha-helix (residues 6-19). The region from residues 20 to 35, which also contains a flexible GxxxG-motif (residues 18-22), appeared to be fairly unstructured in DPC. In the presence of TFE, however, the region between and including residues 23 and 32 formed a well defined alpha-helix. The N-terminal helix between and including residues 6 and 19 seen in the presence of DPC, was broken at residues 8 and 9 in the presence of TFE. The N-terminal helices, both in LcnG-alpha and -beta, are amphiphilic. We postulate that LcnG-alpha and -beta have a parallel orientation and interact through helix-helix interactions involving the first GxxxG (residues 7-11) motif in LcnG-alpha and the one (residues 18-22) in LcnG-beta, and that they thus lie in a staggered fashion relative to each other.


===Lactococcin G-a in TFE===
Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G.,Rogne P, Fimland G, Nissen-Meyer J, Kristiansen PE Biochim Biophys Acta. 2007 Dec 15;. PMID:18187052<ref>PMID:18187052</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18187052}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2jpl" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18187052 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_18187052}}
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</StructureSection>
==About this Structure==
2JPL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPL OCA].
 
==Reference==
Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G., Rogne P, Fimland G, Nissen-Meyer J, Kristiansen PE, Biochim Biophys Acta. 2007 Dec 15;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18187052 18187052]
[[Category: Lactococcus lactis]]
[[Category: Lactococcus lactis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Fimland, G.]]
[[Category: Fimland G]]
[[Category: Kristiansen, P E.]]
[[Category: Kristiansen PE]]
[[Category: Nissen-Meyer, J.]]
[[Category: Nissen-Meyer J]]
[[Category: Rogne, P.]]
[[Category: Rogne P]]
[[Category: Antimicrobial]]
[[Category: Antimicrobial protein]]
[[Category: Membrane bound]]
[[Category: Peptide]]
 
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Retrieved from "https://proteopedia.org/2jpl"