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New page: left|200px<br /><applet load="1oun" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oun, resolution 2.3Å" /> '''CRYSTAL STRUCTURE OF ...
 
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[[Image:1oun.jpg|left|200px]]<br /><applet load="1oun" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1oun, resolution 2.3&Aring;" />
'''CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)'''<br />


==Overview==
==CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)==
Nuclear transport factor 2 (NTF2) facilitates protein transport into the, nucleus and interacts with both the small Ras-like GTPase Ran and, nucleoporin p62. We have determined the structure of bacterially expressed, rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2, polypeptide chain forms an alpha + beta barrel that opens at one end to, form a distinctive hydrophobic cavity and its fold is homologous to that, of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a, potential binding site for other proteins involved in nuclear import such, as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a, putative catalytic Asp-His pair, which raises the possibility of an, unanticipated enzymatic activity of the molecule that may have, implications for the molecular mechanism of nuclear protein import.
<StructureSection load='1oun' size='340' side='right'caption='[[1oun]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1oun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OUN FirstGlance]. <br>
1OUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OUN OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oun OCA], [https://pdbe.org/1oun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oun RCSB], [https://www.ebi.ac.uk/pdbsum/1oun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oun ProSAT]</span></td></tr>
==Reference==
</table>
The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8757804 8757804]
== Function ==
[https://www.uniprot.org/uniprot/NTF2_RAT NTF2_RAT] Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/1oun_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oun ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Bullock TL]]
[[Category: Bullock, T.L.]]
[[Category: Stewart MJ]]
[[Category: Stewart, M.J.]]
[[Category: nuclear transport protein]]
[[Category: transport]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:12:53 2007''

Latest revision as of 08:03, 14 February 2024

CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)

1oun, resolution 2.30Å

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