3bjc: Difference between revisions

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{{Seed}}
[[Image:3bjc.png|left|200px]]


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==Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor==
The line below this paragraph, containing "STRUCTURE_3bjc", creates the "Structure Box" on the page.
<StructureSection load='3bjc' size='340' side='right'caption='[[3bjc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WAN:5-ETHOXY-4-(1-METHYL-7-OXO-3-PROPYL-6,7-DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)THIOPHENE-2-SULFONAMIDE'>WAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3bjc| PDB=3bjc |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjc OCA], [https://pdbe.org/3bjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bjc RCSB], [https://www.ebi.ac.uk/pdbsum/3bjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bjc ConSurf].
<div style="clear:both"></div>


===Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18346713}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18346713 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18346713}}
 
==About this Structure==
3BJC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJC OCA].
 
==Reference==
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies., Chen G, Wang H, Robinson H, Cai J, Wan Y, Ke H, Biochem Pharmacol. 2008 May 1;75(9):1717-28. Epub 2008 Feb 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18346713 18346713]
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cai, J.]]
[[Category: Cai J]]
[[Category: Chen, G.]]
[[Category: Chen G]]
[[Category: Howard, R.]]
[[Category: Howard R]]
[[Category: Ke, H.]]
[[Category: Ke H]]
[[Category: Wan, Y.]]
[[Category: Wan Y]]
[[Category: Wang, H.]]
[[Category: Wang H]]
[[Category: Allosteric enzyme]]
[[Category: Alternative splicing]]
[[Category: Cgmp]]
[[Category: Cgmp-binding]]
[[Category: Crystal structure]]
[[Category: Erectile dysfunction]]
[[Category: Hydrolase]]
[[Category: Inhibitor design]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Nucleotide-binding]]
[[Category: Pde5]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:42:58 2008''

Latest revision as of 09:29, 21 February 2024

Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor

3bjc, resolution 2.00Å

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