2ho2: Difference between revisions

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{{Seed}}
[[Image:2ho2.png|left|200px]]


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==Structure of human FE65-WW domain in complex with hMena peptide.==
The line below this paragraph, containing "STRUCTURE_2ho2", creates the "Structure Box" on the page.
<StructureSection load='2ho2' size='340' side='right'caption='[[2ho2]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ho2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HO2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2ho2|  PDB=2ho2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho2 OCA], [https://pdbe.org/2ho2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho2 ProSAT]</span></td></tr>
 
</table>
===Structure of human FE65-WW domain in complex with hMena peptide.===
== Function ==
 
[https://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/2ho2_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17686488}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2HO2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO2 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ho2 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Structural basis for polyproline recognition by the FE65 WW domain., Meiyappan M, Birrane G, Ladias JA, J Mol Biol. 2007 Sep 28;372(4):970-80. Epub 2007 Jun 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17686488 17686488]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Birrane, G.]]
[[Category: Birrane G]]
[[Category: Ladias, J A.]]
[[Category: Ladias JA]]
[[Category: Meiyappan, M.]]
[[Category: Meiyappan M]]
[[Category: Beta sheet]]
[[Category: Fe65]]
[[Category: Protein binding]]
[[Category: Ww domain]]
[[Category: X-ray]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:08:33 2008''
Retrieved from "https://proteopedia.org/2ho2"