2oki: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2oki.png|left|200px]]


<!--
==Crystal structure of dimeric form of PfFabZ in crystal form2==
The line below this paragraph, containing "STRUCTURE_2oki", creates the "Structure Box" on the page.
<StructureSection load='2oki' size='340' side='right'caption='[[2oki]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2oki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oki OCA], [https://pdbe.org/2oki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oki RCSB], [https://www.ebi.ac.uk/pdbsum/2oki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oki ProSAT]</span></td></tr>
{{STRUCTURE_2oki|  PDB=2oki  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q965D7_PLAFA Q965D7_PLAFA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/2oki_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oki ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystals obtained from various batches of crystallization trials of FabZ from Plasmodium falciparum exhibited non-isomorphism. The c axis of the I222 cell showed a large variation of about 16 A, from c = 81 A to c = 97 A. Complete data sets were collected for three crystal forms with varying lengths of the c axis (form 1, c = 97 A; form 2, c = 92 A; form 3, c = 81 A). The crystal structure of form 1 has been reported previously. Here, the crystal structures of the other two crystal forms are reported and a detailed structural comparison is made of the three crystal forms in order to explore the possible reasons for the existence of non-isomorphism. The conformations of three loops vary between the three crystal forms. The disposition of the loops affects the crystal packing and hence the unit-cell parameter. The crystallization condition and crystallization method employed, which change the evaporation rate, determine the crystal form of the enzyme. The present analysis shows that pH-induced intrinsic conformational changes in the protein play a key role in the observed differences.


===Crystal structure of dimeric form of PfFabZ in crystal form2===
Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum.,Swarnamukhi PL, Sharma SK, Padala P, Surolia N, Surolia A, Suguna K Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):458-64. Epub 2007, Mar 16. PMID:17372349<ref>PMID:17372349</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2oki" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17372349}}, adds the Publication Abstract to the page
*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17372349 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17372349}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2OKI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKI OCA].
 
==Reference==
Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum., Swarnamukhi PL, Sharma SK, Padala P, Surolia N, Surolia A, Suguna K, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):458-64. Epub 2007, Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372349 17372349]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Single protein]]
[[Category: Padala P]]
[[Category: Padala, P.]]
[[Category: Sharma SK]]
[[Category: Sharma, S K.]]
[[Category: Suguna K]]
[[Category: Suguna, K.]]
[[Category: Surolia A]]
[[Category: Surolia, A.]]
[[Category: Surolia N]]
[[Category: Surolia, N.]]
[[Category: Swarnamukhi PL]]
[[Category: Swarnamukhi, P L.]]
[[Category: Fabz]]
[[Category: Hotdog fold]]
[[Category: Non-isomorphism]]
[[Category: Plasmodium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:26:47 2008''

Latest revision as of 08:57, 25 October 2023

Crystal structure of dimeric form of PfFabZ in crystal form2

2oki, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2oki&oldid=3925585"