2b07: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2b07.png|left|200px]]


<!--
==Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.==
The line below this paragraph, containing "STRUCTURE_2b07", creates the "Structure Box" on the page.
<StructureSection load='2b07' size='340' side='right'caption='[[2b07]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2b07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B07 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=598:6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>598</scene></td></tr>
{{STRUCTURE_2b07| PDB=2b07 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b07 OCA], [https://pdbe.org/2b07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b07 RCSB], [https://www.ebi.ac.uk/pdbsum/2b07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b07 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b07_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b07 ConSurf].
<div style="clear:both"></div>


===Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.===
==See Also==
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16303309}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_16303309}}
 
==About this Structure==
2B07 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA].
 
==Reference==
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16303309 16303309]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Binnun E]]
[[Category: Binnun, E.]]
[[Category: Erbe DV]]
[[Category: Erbe, D V.]]
[[Category: Follows BC]]
[[Category: Follows, B C.]]
[[Category: Foreman K]]
[[Category: Foreman, K.]]
[[Category: Joseph-McCarthy D]]
[[Category: Joseph-McCarthy, D.]]
[[Category: Kirincich SJ]]
[[Category: Kirincich, S J.]]
[[Category: Lee J]]
[[Category: Lee, J.]]
[[Category: Moretto AF]]
[[Category: Moretto, A F.]]
[[Category: Smith MJ]]
[[Category: Smith, M J.]]
[[Category: Tam SK]]
[[Category: Tam, S K.]]
[[Category: Tam SY]]
[[Category: Tam, S Y.]]
[[Category: Wan ZK]]
[[Category: Wan, Z K.]]
[[Category: Wilson DP]]
[[Category: Wilson, D P.]]
[[Category: Xu WX]]
[[Category: Xu, W X.]]
[[Category: Zhang YL]]
[[Category: Zhang, Y L.]]
[[Category: Hydrolyase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Tricyclic thiophene]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:47 2008''
Retrieved from "https://proteopedia.org/2b07"