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{{Seed}}
[[Image:1qet.png|left|200px]]


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==TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1qet", creates the "Structure Box" on the page.
<StructureSection load='1qet' size='340' side='right'caption='[[1qet]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qet]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QET FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qet OCA], [https://pdbe.org/1qet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qet RCSB], [https://www.ebi.ac.uk/pdbsum/1qet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qet ProSAT]</span></td></tr>
{{STRUCTURE_1qet|  PDB=1qet  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The symmetric, tandem GU mismatch motifs, and , which only differ in the mismatch order, have an average difference in thermodynamic stability of 2 kcal/mol at 37 degrees C. Thermodynamic studies of duplexes containing these motifs indicate the effect is largely localized to the mismatches and adjacent base pairs. The three-dimensional structures of two representative duplexes, (rGGAGUUCC)2 and (rGGAUGUCC)2, were determined by two-dimensional NMR and a simulated annealing protocol. Local deviations are similar to other intrahelical GU mismatches with little effect on backbone torsion angles and a slight overtwisting between the base pair 5' of the G of the mismatch and the mismatch itself. Comparisons of the resulting stacking patterns along with electrostatic potential maps suggest that interactions between highly negative electrostatic regions between base pairs may play a role in the observed thermodynamic differences.


===TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES===
Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2.,McDowell JA, He L, Chen X, Turner DH Biochemistry. 1997 Jul 1;36(26):8030-8. PMID:9201950<ref>PMID:9201950</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_9201950}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1qet" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9201950 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_9201950}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA].
[[Category: Chen X]]
 
[[Category: He L]]
==Reference==
[[Category: Mcdowell JA]]
Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2., McDowell JA, He L, Chen X, Turner DH, Biochemistry. 1997 Jul 1;36(26):8030-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9201950 9201950]
[[Category: Turner DH]]
[[Category: Chen, X.]]
[[Category: He, L.]]
[[Category: Mcdowell, J A.]]
[[Category: Turner, D H.]]
[[Category: G:u mismatch]]
[[Category: Ribonucleic acid]]
 
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Latest revision as of 09:19, 6 December 2023

TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES

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