1pks: Difference between revisions

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{{Seed}}
[[Image:1pks.png|left|200px]]


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==STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY==
The line below this paragraph, containing "STRUCTURE_1pks", creates the "Structure Box" on the page.
<StructureSection load='1pks' size='340' side='right'caption='[[1pks]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pks OCA], [https://pdbe.org/1pks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pks RCSB], [https://www.ebi.ac.uk/pdbsum/1pks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pks ProSAT]</span></td></tr>
{{STRUCTURE_1pks| PDB=1pks |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pks_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pks ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY===
==See Also==
 
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 7681364 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_7681364}}
 
==About this Structure==
1PKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKS OCA].
 
==Reference==
Structure of the PI3K SH3 domain and analysis of the SH3 family., Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL, Cell. 1993 Mar 26;72(6):945-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7681364 7681364]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Dalgarno DC]]
[[Category: Dalgarno, D C.]]
[[Category: Koyama S]]
[[Category: Koyama, S.]]
[[Category: Schreiber SL]]
[[Category: Schreiber, S L.]]
[[Category: Shin TB]]
[[Category: Shin, T B.]]
[[Category: Yu H]]
[[Category: Yu, H.]]
[[Category: Zydowsky LD]]
[[Category: Zydowsky, L D.]]
[[Category: Phosphotransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:17:30 2008''
Retrieved from "https://proteopedia.org/1pks"