1n96: Difference between revisions

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[[Image:1n96.png|left|200px]]


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==DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)==
The line below this paragraph, containing "STRUCTURE_1n96", creates the "Structure Box" on the page.
<StructureSection load='1n96' size='340' side='right'caption='[[1n96]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1n96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N96 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n96 OCA], [https://pdbe.org/1n96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n96 RCSB], [https://www.ebi.ac.uk/pdbsum/1n96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n96 ProSAT]</span></td></tr>
{{STRUCTURE_1n96|  PDB=1n96  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of a cyclic oligonucleotide d&lt;pCGCTCATT&gt; has been determined by two-dimensional NMR spectroscopy and restrained molecular dynamics. Under the appropriate experimental conditions, this molecule self-associates, forming a symmetric dimer stabilized by four intermolecular Watson-Crick base pairs. The resulting four-stranded structure consists of two G:C:A:T tetrads, formed by facing the minor groove side of the Watson-Crick base-pairs. Most probably, the association of the base-pairs is stabilized by coordinating a Na(+) cation. This is the first time that this novel G:C:A:T tetrad has been found in an oligonucleotide structure. This observation increases considerably the number of sequences that may adopt a four-stranded architecture. Overall, the three-dimensional structure is similar to those observed previously in other quadruplexes formed by minor groove alignment of Watson-Crick base pairs. This resemblance strongly suggests that we may be observing a general motif for DNA-DNA recognition.


===DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)===
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad.,Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:12733903<ref>PMID:12733903</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1n96" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 12733903 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_12733903}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA].
[[Category: Escaja N]]
 
[[Category: Gelpi JL]]
==Reference==
[[Category: Gonzalez C]]
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad., Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C, J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12733903 12733903]
[[Category: Orozco M]]
[[Category: Escaja, N.]]
[[Category: Pedroso E]]
[[Category: Gelpi, J L.]]
[[Category: Rico M]]
[[Category: Gonzalez, C.]]
[[Category: Orozco, M.]]
[[Category: Pedroso, E.]]
[[Category: Rico, M.]]
[[Category: Bi-loop]]
[[Category: Four-stranded dna]]
[[Category: Quadruplex]]
[[Category: Unusual dna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:28:37 2008''

Latest revision as of 18:52, 29 November 2023

DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)

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