1y2t: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1y2t.png|left|200px]]


<!--
==Crystal structure of the common edible mushroom (Agaricus bisporus) lectin==
The line below this paragraph, containing "STRUCTURE_1y2t", creates the "Structure Box" on the page.
<StructureSection load='1y2t' size='340' side='right'caption='[[1y2t]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2t OCA], [https://pdbe.org/1y2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2t RCSB], [https://www.ebi.ac.uk/pdbsum/1y2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2t ProSAT]</span></td></tr>
{{STRUCTURE_1y2t|  PDB=1y2t  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the common edible mushroom (Agaricus bisporus) lectin===
[https://www.uniprot.org/uniprot/ABL_AGABI ABL_AGABI] Lectin that recognizes O-linked galactose-beta-1,3-N-acetylgalactosamine, a disaccharide (Thomsen-Friedenreich antigen or T-disaccharide), present on cell surface glycoproteins. Can also bind galactose-beta-1,3-N-acetylglucosamine. Does not bind monosaccharides. Can be internalized by clathrin-coated vesicles after binding to surface glycoproteins. After internalization it inhibits nuclear import of nuclear localization signal dependent proteins. Inhibits proliferation of malignant cells without cytotoxicity for normal cells.<ref>PMID:4343164</ref> <ref>PMID:8402638</ref> <ref>PMID:9988731</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_15596442}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 15596442 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2t_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_15596442}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2t ConSurf].
1Y2T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2T OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The antineoplastic lectin of the common edible mushroom (Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl., Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL, J Biol Chem. 2005 Mar 18;280(11):10614-23. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15596442 15596442]
__TOC__
 
</StructureSection>
Crystallization and preliminary X-ray study of the common edible mushroom (Agaricus bisporus) lectin., Carrizo ME, Irazoqui FJ, Lardone RD, Nores GA, Curtino JA, Capaldi S, Perduca M, Monaco HL, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):718-20. Epub 2004, Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15039564 15039564]
[[Category: Agaricus bisporus]]
[[Category: Single protein]]
[[Category: Capaldi, S.]]
[[Category: Carrizo, M E.]]
[[Category: Irazoqui, F J.]]
[[Category: Monaco, H L.]]
[[Category: Nores, G A.]]
[[Category: Perduca, M.]]
[[Category: Abl]]
[[Category: Agaricus bisporus]]
[[Category: Agaricus bisporus]]
[[Category: Lectin]]
[[Category: Large Structures]]
[[Category: Mushroom]]
[[Category: Capaldi S]]
 
[[Category: Carrizo ME]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:05:19 2008''
[[Category: Irazoqui FJ]]
[[Category: Monaco HL]]
[[Category: Nores GA]]
[[Category: Perduca M]]
Retrieved from "https://proteopedia.org/1y2t"