1pe5: Difference between revisions

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New page: left|200px<br /><applet load="1pe5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pe5, resolution 1.70Å" /> '''Thermolysin with tri...
 
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[[Image:1pe5.gif|left|200px]]<br /><applet load="1pe5" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1pe5, resolution 1.70&Aring;" />
'''Thermolysin with tricyclic inhibitor'''<br />


==About this Structure==
==Thermolysin with tricyclic inhibitor==
1PE5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus] with ZN, CA, BR3 and LEU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PE5 OCA].  
<StructureSection load='1pe5' size='340' side='right'caption='[[1pe5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PE5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR3:(6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE'>BR3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LEN:3-METHYLBUTAN-1-AMINE'>LEN</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe5 OCA], [https://pdbe.org/1pe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pe5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pe5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/1pe5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pe5 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Thermolysin 3D structures|Thermolysin 3D structures]]
__TOC__
</StructureSection>
[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thermolysin]]
[[Category: Bartlett PA]]
[[Category: Bartlett, P.A.]]
[[Category: Holland D]]
[[Category: Holland, D.]]
[[Category: Juers D]]
[[Category: Juers, D.]]
[[Category: Matthews BW]]
[[Category: Matthews, B.W.]]
[[Category: Morgan BP]]
[[Category: Morgan, B.P.]]
[[Category: BR3]]
[[Category: CA]]
[[Category: LEU]]
[[Category: ZN]]
[[Category: hydrolase]]
[[Category: metalloprotease]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:43:46 2007''

Latest revision as of 08:07, 14 February 2024

Thermolysin with tricyclic inhibitor

1pe5, resolution 1.70Å

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