1z8a: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1z8a.png|left|200px]]


<!--
==Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor==
The line below this paragraph, containing "STRUCTURE_1z8a", creates the "Structure Box" on the page.
<StructureSection load='1z8a' size='340' side='right'caption='[[1z8a]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1z8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62P:6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE'>62P</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_1z8a| PDB=1z8a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8a OCA], [https://pdbe.org/1z8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8a RCSB], [https://www.ebi.ac.uk/pdbsum/1z8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8a ConSurf].
<div style="clear:both"></div>


===Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor===
==See Also==
 
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16337231}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16337231 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16337231}}
 
==About this Structure==
1Z8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].
 
==Reference==
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group., Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G, J Mol Biol. 2006 Feb 10;356(1):45-56. Epub 2005 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16337231 16337231]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Heine, A.]]
[[Category: Heine A]]
[[Category: Klebe, G.]]
[[Category: Klebe G]]
[[Category: Podjarny, A.]]
[[Category: Podjarny A]]
[[Category: Steuber, H.]]
[[Category: Steuber H]]
[[Category: Zentgraf, M.]]
[[Category: Zentgraf M]]
[[Category: Double conformation]]
[[Category: Protein-ligand complex]]
[[Category: Tim-barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:20:51 2008''

Latest revision as of 13:39, 13 March 2024

Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor

1z8a, resolution 0.95Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1z8a&oldid=4088274"