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New page: left|200px<br /><applet load="1pho" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pho, resolution 3.0Å" /> '''CRYSTAL STRUCTURES EX...
 
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[[Image:1pho.gif|left|200px]]<br /><applet load="1pho" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1pho, resolution 3.0&Aring;" />
'''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''<br />


==Overview==
==CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS==
Porins form aqueous channels that aid the diffusion of small hydrophilic, molecules across the outer membrane of Gram-negative bacteria. The crystal, structures of matrix porin and phosphoporin both reveal trimers of, identical subunits, each subunit consisting of a 16-stranded anti-parallel, beta-barrel containing a pore. A long loop inside the barrel contributes, to a constriction of the channel where the charge distribution affects ion, selectivity. The structures explain at the molecular level functional, characteristics and their alterations by known mutations.
<StructureSection load='1pho' size='340' side='right'caption='[[1pho]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PHO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pho OCA], [https://pdbe.org/1pho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pho RCSB], [https://www.ebi.ac.uk/pdbsum/1pho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pho ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHOE_ECOLI PHOE_ECOLI] Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/1pho_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pho ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1PHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA].
*[[Porin 3D structures|Porin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structures explain functional properties of two E. coli porins., Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP, Nature. 1992 Aug 27;358(6389):727-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1380671 1380671]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cowan, S.W.]]
[[Category: Cowan SW]]
[[Category: Jansonius, J.N.]]
[[Category: Jansonius JN]]
[[Category: Schirmer, T.]]
[[Category: Schirmer T]]
[[Category: outer membrane protein]]
 
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