1o83: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1o83.png|left|200px]]


<!--
==Crystal Structure of Bacteriocin AS-48 at pH 7.5, phosphate bound. Crystal form I==
The line below this paragraph, containing "STRUCTURE_1o83", creates the "Structure Box" on the page.
<StructureSection load='1o83' size='340' side='right'caption='[[1o83]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1o83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O83 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_1o83|  PDB=1o83  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o83 OCA], [https://pdbe.org/1o83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o83 RCSB], [https://www.ebi.ac.uk/pdbsum/1o83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o83 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q47765_ENTFL Q47765_ENTFL]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bacteriocin AS-48 is a membrane-interacting peptide, which displays a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. The NMR structure of AS-48 at pH 3 has been solved. The analysis of this structure suggests that the mechanism of AS-48 anti-bacterial activity involves the accumulation of positively charged molecules at the membrane surface leading to a disruption of the membrane potential. Here, we report the high-resolution crystal structure of AS-48 and sedimentation equilibrium experiments showing that this bacteriocin is able to adopt different oligomeric structures according to the physicochemical environment. The analysis of these structures suggests a mechanism for molecular function of AS-48 involving a transition from a water-soluble form to a membrane-bound state upon membrane binding.


===CRYSTAL STRUCTURE OF BACTERIOCIN AS-48 AT PH 7.5, PHOSPHATE BOUND. CRYSTAL FORM I===
Structure of bacteriocin AS-48: from soluble state to membrane bound state.,Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:14623193<ref>PMID:14623193</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_14623193}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1o83" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 14623193 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_14623193}}
__TOC__
 
</StructureSection>
==About this Structure==
1O83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O83 OCA].
 
==Reference==
Structure of bacteriocin AS-48: from soluble state to membrane bound state., Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A, J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14623193 14623193]
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Albert, A.]]
[[Category: Albert A]]
[[Category: Cruz, V.]]
[[Category: Cruz V]]
[[Category: Galvez, A.]]
[[Category: Galvez A]]
[[Category: Maqueda, M.]]
[[Category: Maqueda M]]
[[Category: Martinez-Ripoll, M.]]
[[Category: Martinez-Ripoll M]]
[[Category: Sanchez-Barrena, M J.]]
[[Category: Sanchez-Barrena MJ]]
[[Category: Valdivia, E.]]
[[Category: Valdivia E]]
[[Category: Antibacterial peptide]]
[[Category: Bacteriocin]]
[[Category: Cyclic polypeptide]]
[[Category: Membrane permeabilization]]
[[Category: Protein crystallography]]
[[Category: Protein membrane interaction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:45:30 2008''
Retrieved from "https://proteopedia.org/1o83"