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{{Seed}}
[[Image:1sq9.png|left|200px]]


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==Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination==
The line below this paragraph, containing "STRUCTURE_1sq9", creates the "Structure Box" on the page.
<StructureSection load='1sq9' size='340' side='right'caption='[[1sq9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1sq9|  PDB=1sq9  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq9 OCA], [https://pdbe.org/1sq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq9 ProSAT]</span></td></tr>
 
</table>
===Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination===
== Function ==
 
[https://www.uniprot.org/uniprot/SKI8_YEAST SKI8_YEAST] Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.<ref>PMID:6371496</ref> <ref>PMID:3029964</ref> <ref>PMID:7739557</ref> <ref>PMID:9258672</ref> <ref>PMID:9482746</ref> <ref>PMID:10744028</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:14671320</ref> <ref>PMID:15044957</ref> <ref>PMID:14992724</ref> <ref>PMID:16816949</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15152089}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq9_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15152089}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1SQ9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ9 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq9 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure., Madrona AY, Wilson DK, Protein Sci. 2004 Jun;13(6):1557-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15152089 15152089]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Madrona AY]]
[[Category: Madrona, A Y.]]
[[Category: Wilson DK]]
[[Category: Wilson, D K.]]
[[Category: Beta propeller]]
[[Category: Beta-transducin repeat]]
[[Category: Wd repeat]]
[[Category: Wd40 repeat]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:00:16 2008''

Latest revision as of 08:32, 14 February 2024

Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination

1sq9, resolution 1.90Å

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