2gpo: Difference between revisions

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{{Seed}}
[[Image:2gpo.png|left|200px]]


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==Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140==
The line below this paragraph, containing "STRUCTURE_2gpo", creates the "Structure Box" on the page.
<StructureSection load='2gpo' size='340' side='right'caption='[[2gpo]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2gpo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpo OCA], [https://pdbe.org/2gpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpo RCSB], [https://www.ebi.ac.uk/pdbsum/2gpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpo ProSAT]</span></td></tr>
{{STRUCTURE_2gpo| PDB=2gpo |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/2gpo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gpo ConSurf].
<div style="clear:both"></div>


===Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140===
==See Also==
 
*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16990259}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16990259 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_16990259}}
 
==About this Structure==
2GPO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPO OCA].
 
==Reference==
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation., Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT, J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990259 16990259]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Consler, T G.]]
[[Category: Consler TG]]
[[Category: Lambert, M H.]]
[[Category: Lambert MH]]
[[Category: McKee, D D.]]
[[Category: McKee DD]]
[[Category: Miller, A B.]]
[[Category: Miller AB]]
[[Category: Nolte, R T.]]
[[Category: Nolte RT]]
[[Category: Osband-miller, L A.]]
[[Category: Osband-miller LA]]
[[Category: Wang, L.]]
[[Category: Wang L]]
[[Category: Willson, T M.]]
[[Category: Willson TM]]
[[Category: Zuercher, W J.]]
[[Category: Zuercher WJ]]
[[Category: Err]]
[[Category: Errg]]
[[Category: Esrrg]]
[[Category: Estrogen related receptor]]
[[Category: Nuclear receptor]]
[[Category: Rip140]]
[[Category: Steroid receptor]]
[[Category: Transcription]]
 
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Retrieved from "https://proteopedia.org/2gpo"