2v2h: Difference between revisions

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{{Seed}}
[[Image:2v2h.png|left|200px]]


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==The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM==
The line below this paragraph, containing "STRUCTURE_2v2h", creates the "Structure Box" on the page.
<StructureSection load='2v2h' size='340' side='right'caption='[[2v2h]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2v2h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
{{STRUCTURE_2v2h| PDB=2v2h |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2h OCA], [https://pdbe.org/2v2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2h RCSB], [https://www.ebi.ac.uk/pdbsum/2v2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2h ConSurf].
<div style="clear:both"></div>


===THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM===
==See Also==
 
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_18219118}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18219118 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18219118}}
 
==About this Structure==
2V2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2H OCA].
 
==Reference==
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM., Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK, Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18219118 18219118]
[[Category: Single protein]]
[[Category: Triose-phosphate isomerase]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Alahuhta, M.]]
[[Category: Alahuhta M]]
[[Category: Casteleijn, M G.]]
[[Category: Casteleijn MG]]
[[Category: Neubauer, P.]]
[[Category: Neubauer P]]
[[Category: Wierenga, R K.]]
[[Category: Wierenga RK]]
[[Category: 2-phospho glycolate]]
[[Category: 2pg]]
[[Category: A178l]]
[[Category: Engineering]]
[[Category: Enzyme]]
[[Category: Fatty acid biosynthesis]]
[[Category: Gluconeogenesis]]
[[Category: Glycolysis]]
[[Category: Glycosome]]
[[Category: Hinge]]
[[Category: Isomerase]]
[[Category: Lipid synthesis]]
[[Category: Loop-6]]
[[Category: Loop6]]
[[Category: Monomeric]]
[[Category: Pentose shunt]]
[[Category: Point mutation]]
[[Category: Tim]]
[[Category: Tim-barrel]]
[[Category: Triosephosphate isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:56:10 2008''

Latest revision as of 07:06, 1 May 2024

The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM

2v2h, resolution 1.18Å

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