1rgx: Difference between revisions

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{{Seed}}
[[Image:1rgx.png|left|200px]]


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==Crystal Structure of resisitin==
The line below this paragraph, containing "STRUCTURE_1rgx", creates the "Structure Box" on the page.
<StructureSection load='1rgx' size='340' side='right'caption='[[1rgx]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1rgx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RGX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.787&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rgx OCA], [https://pdbe.org/1rgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rgx RCSB], [https://www.ebi.ac.uk/pdbsum/1rgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rgx ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1rgx TOPSAN]</span></td></tr>
{{STRUCTURE_1rgx|  PDB=1rgx  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RETN_MOUSE RETN_MOUSE] Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.<ref>PMID:11201732</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/1rgx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rgx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.


===Crystal Structure of resisitin===
Disulfide-dependent multimeric assembly of resistin family hormones.,Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L Science. 2004 May 21;304(5674):1154-8. PMID:15155948<ref>PMID:15155948</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1rgx" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15155948 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_15155948}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1RGX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGX OCA].
 
==Reference==
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15155948 15155948]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Burley SK]]
[[Category: Burley, S K.]]
[[Category: Patel SD]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Rajala MW]]
[[Category: Patel, S D.]]
[[Category: Scherer PE]]
[[Category: Rajala, M W.]]
[[Category: Shapiro L]]
[[Category: Scherer, P E.]]
[[Category: Shapiro, L.]]
[[Category: Glucose uptake]]
[[Category: Hormone]]
[[Category: New york structural genomix research consortium]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Resistin/fizz family]]
[[Category: Structural genomic]]
 
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Retrieved from "https://proteopedia.org/1rgx"