2j3p: Difference between revisions

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{{Seed}}
[[Image:2j3p.png|left|200px]]


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==crystal structure of rat FGF1 at 1.4 A==
The line below this paragraph, containing "STRUCTURE_2j3p", creates the "Structure Box" on the page.
<StructureSection load='2j3p' size='340' side='right'caption='[[2j3p]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2j3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J3P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2j3p|  PDB=2j3p  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j3p OCA], [https://pdbe.org/2j3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j3p RCSB], [https://www.ebi.ac.uk/pdbsum/2j3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j3p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FGF1_RAT FGF1_RAT] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j3p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j3p ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.


===CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A===
Structure of rat acidic fibroblast growth factor at 1.4 A resolution.,Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:17277441<ref>PMID:17277441</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2j3p" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17277441}}, adds the Publication Abstract to the page
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17277441 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17277441}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2J3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA].
 
==Reference==
Structure of rat acidic fibroblast growth factor at 1.4 A resolution., Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17277441 17277441]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Berezin V]]
[[Category: Berezin, V.]]
[[Category: Bock E]]
[[Category: Bock, E.]]
[[Category: Gajhede M]]
[[Category: Gajhede, M.]]
[[Category: Kristensen O]]
[[Category: Kristensen, O.]]
[[Category: Kulahin N]]
[[Category: Kulahin, N.]]
[[Category: Acidic fibroblast growth factor]]
[[Category: Angiogenesis]]
[[Category: Beta-trefoil]]
[[Category: Cytokine]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Growth factor]]
[[Category: Heparin-binding]]
[[Category: Mitogen]]
 
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Retrieved from "https://proteopedia.org/2j3p"