2b6f: Difference between revisions

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{{Seed}}
[[Image:2b6f.png|left|200px]]


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==Solution structure of human sulfiredoxin (SRX)==
The line below this paragraph, containing "STRUCTURE_2b6f", creates the "Structure Box" on the page.
<StructureSection load='2b6f' size='340' side='right'caption='[[2b6f]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2b6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2b6f|  PDB=2b6f  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6f OCA], [https://pdbe.org/2b6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6f RCSB], [https://www.ebi.ac.uk/pdbsum/2b6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6f ProSAT]</span></td></tr>
 
</table>
===Solution structure of human sulfiredoxin (SRX)===
== Function ==
 
[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17176052}}, adds the Publication Abstract to the page
Check<jmol>
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  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6f_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17176052}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2B6F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6F OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6f ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis., Lee DY, Park SJ, Jeong W, Sung HJ, Oho T, Wu X, Rhee SG, Gruschus JM, Biochemistry. 2006 Dec 26;45(51):15301-9. Epub 2006 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17176052 17176052]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ferretti, J A.]]
[[Category: Ferretti JA]]
[[Category: Gruschus, J M.]]
[[Category: Gruschus JM]]
[[Category: Lee, D Y.]]
[[Category: Lee D-Y]]
[[Category: Rhee, S G.]]
[[Category: Rhee SG]]
[[Category: Parb domain fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:51:22 2008''

Latest revision as of 06:37, 1 May 2024

Solution structure of human sulfiredoxin (SRX)

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