2g7o: Difference between revisions

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{{Seed}}
[[Image:2g7o.png|left|200px]]


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==Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM==
The line below this paragraph, containing "STRUCTURE_2g7o", creates the "Structure Box" on the page.
<StructureSection load='2g7o' size='340' side='right'caption='[[2g7o]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2g7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7O FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7o OCA], [https://pdbe.org/2g7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7o RCSB], [https://www.ebi.ac.uk/pdbsum/2g7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7o ProSAT]</span></td></tr>
{{STRUCTURE_2g7o|  PDB=2g7o  |  SCENE=  }}
</table>
 
== Function ==
===Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM===
[https://www.uniprot.org/uniprot/TRAM1_ECOLI TRAM1_ECOLI] Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Cooperatively binds 3 regions in the F plasmid oriT locus; 2 are required for autoregulation while the other is required for plasmid transfer. Bends oriT DNA less than 50 degrees. Plasmid specificity is conferred by the TraD-TraM pair.<ref>PMID:1479887</ref> <ref>PMID:8736534</ref> <ref>PMID:11875064</ref> <ref>PMID:17238924</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_16710295}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16710295 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7o_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_16710295}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7o ConSurf].
2G7O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7O OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM., Lu J, Edwards RA, Wong JJ, Manchak J, Scott PG, Frost LS, Glover JN, EMBO J. 2006 Jun 21;25(12):2930-9. Epub 2006 May 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16710295 16710295]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Edwards, R A.]]
[[Category: Edwards RA]]
[[Category: Frost, L S.]]
[[Category: Frost LS]]
[[Category: Glover, J N.]]
[[Category: Glover JN]]
[[Category: Lu, J.]]
[[Category: Lu J]]
[[Category: Manchak, J.]]
[[Category: Manchak J]]
[[Category: Scott, P G.]]
[[Category: Scott PG]]
[[Category: Wong, J J.]]
[[Category: Wong JJ]]
[[Category: Four helix bundle]]
[[Category: Tetramer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:48:32 2008''
Retrieved from "https://proteopedia.org/2g7o"