1su2: Difference between revisions

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{{Seed}}
[[Image:1su2.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE NUDIX HYDROLASE DR1025 IN COMPLEX WITH ATP==
The line below this paragraph, containing "STRUCTURE_1su2", creates the "Structure Box" on the page.
<StructureSection load='1su2' size='340' side='right'caption='[[1su2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1su2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SU2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1su2| PDB=1su2 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1su2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1su2 OCA], [https://pdbe.org/1su2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1su2 RCSB], [https://www.ebi.ac.uk/pdbsum/1su2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1su2 ProSAT], [https://www.topsan.org/Proteins/BSGC/1su2 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Y1025_DEIRA Y1025_DEIRA] Hydrolase that can act as a nucleoside triphosphatase and a dinucleoside polyphosphate pyrophosphatase. The best substrates are 8-oxo-dGTP and 8-oxo-GTP. Other substrates include Ap4A, dGTP and GTP. May be involved in protection from damage caused by radiation.<ref>PMID:23481913</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1su2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1su2 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE NUDIX HYDROLASE DR1025 IN COMPLEX WITH ATP===
==See Also==
 
*[[Nudix hydrolase|Nudix hydrolase]]
 
*[[Nudix hydrolase 3D structures|Nudix hydrolase 3D structures]]
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
The line below this paragraph, {{ABSTRACT_PUBMED_15123424}}, adds the Publication Abstract to the page
== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 15123424 is the PubMed ID number.
<references/>
-->
__TOC__
{{ABSTRACT_PUBMED_15123424}}
</StructureSection>
 
==About this Structure==
1SU2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SU2 OCA].
 
==Reference==
Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes., Ranatunga W, Hill EE, Mooster JL, Holbrook EL, Schulze-Gahmen U, Xu W, Bessman MJ, Brenner SE, Holbrook SR, J Mol Biol. 2004 May 21;339(1):103-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15123424 15123424]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Bessman MJ]]
[[Category: Bessman, M J.]]
[[Category: Brenner SE]]
[[Category: Brenner, S E.]]
[[Category: Hill EE]]
[[Category: Hill, E E.]]
[[Category: Holbrook EL]]
[[Category: Holbrook, E L.]]
[[Category: Holbrook SR]]
[[Category: Holbrook, S R.]]
[[Category: Mooster JL]]
[[Category: Mooster, J L.]]
[[Category: Ranatunga W]]
[[Category: Ranatunga, W.]]
[[Category: Schulze-Gahmen U]]
[[Category: Schulze-Gahmen, U.]]
[[Category: Xu W]]
[[Category: Xu, W.]]
[[Category: Alpha-beta-alpha sandwich]]
[[Category: Berkeley structural genomics center]]
[[Category: Bsgc structure funded by nih]]
[[Category: Nudix fold]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
 
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Retrieved from "https://proteopedia.org/1su2"