1q60: Difference between revisions
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New page: left|200px<br /><applet load="1q60" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q60" /> '''Solution Structure of RSGI RUH-004, a GTF2I ... |
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== | ==Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA== | ||
<StructureSection load='1q60' size='340' side='right'caption='[[1q60]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1q60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q60 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q60 OCA], [https://pdbe.org/1q60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q60 RCSB], [https://www.ebi.ac.uk/pdbsum/1q60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q60 ProSAT], [https://www.topsan.org/Proteins/RSGI/1q60 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GTF2I_MOUSE GTF2I_MOUSE] Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q60_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q60 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Doi-Katayama Y]] | |||
[[Category: Doi-Katayama | [[Category: Hayashi F]] | ||
[[Category: Hayashi | [[Category: Hirota H]] | ||
[[Category: Hirota | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 06:01, 17 April 2024
Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
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