2f35: Difference between revisions

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{{Seed}}
[[Image:2f35.png|left|200px]]


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==Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution==
The line below this paragraph, containing "STRUCTURE_2f35", creates the "Structure Box" on the page.
<StructureSection load='2f35' size='340' side='right'caption='[[2f35]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F35 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UBC:(S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE'>UBC</scene></td></tr>
{{STRUCTURE_2f35| PDB=2f35 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f35 OCA], [https://pdbe.org/2f35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f35 RCSB], [https://www.ebi.ac.uk/pdbsum/2f35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f35 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f35_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f35 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution===
==See Also==
 
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 16540562 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16540562}}
 
==About this Structure==
2F35 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F35 OCA].
 
==Reference==
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists., Mayer ML, Ghosal A, Dolman NP, Jane DE, J Neurosci. 2006 Mar 15;26(11):2852-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16540562 16540562]
 
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity., Mayer ML, Neuron. 2005 Feb 17;45(4):539-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721240 15721240]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Mayer ML]]
[[Category: Mayer, M L.]]
[[Category: Membrane protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:18 2008''

Latest revision as of 09:21, 14 February 2024

Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution

2f35, resolution 1.87Å

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