2k2g: Difference between revisions

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{{Seed}}
[[Image:2k2g.png|left|200px]]


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==Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor==
The line below this paragraph, containing "STRUCTURE_2k2g", creates the "Structure Box" on the page.
<StructureSection load='2k2g' size='340' side='right'caption='[[2k2g]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2k2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSV:N-(DIBENZO[B,D]THIOPHEN-3-YLSULFONYL)-L-VALINE'>DSV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2k2g| PDB=2k2g |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2g OCA], [https://pdbe.org/2k2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2g RCSB], [https://www.ebi.ac.uk/pdbsum/2k2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2g ConSurf].
<div style="clear:both"></div>


===Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor===
==See Also==
 
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2K2G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2G OCA].
 
==Reference==
Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor., Markus MA, Dwyer B, Wolfrom S, Li J, Li W, Malakian K, Wilhelm J, Tsao DH, J Biomol NMR. 2008 May;41(1):55-60. Epub 2008 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18425585 18425585]
 
1H, 13C, and 15N assignments of MMP-12, a key protease implicated in lung tissue remodeling., Markus MA, Dwyer B, Wolfrom S, Li J, Li W, Malakian K, Wilhelm J, Tsao DH, J Biomol NMR. 2005 Mar;31(3):260. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15803400 15803400]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Dwyer B]]
[[Category: Dwyer, B.]]
[[Category: Li J]]
[[Category: Li, J.]]
[[Category: Li W]]
[[Category: Li, W.]]
[[Category: Malakian K]]
[[Category: Malakian, K.]]
[[Category: Markus MA]]
[[Category: Markus, M A.]]
[[Category: Tsao DHH]]
[[Category: Tsao, D H.H.]]
[[Category: Wilhelm J]]
[[Category: Wilhelm, J.]]
[[Category: Wolfrom S]]
[[Category: Wolfrom, S.]]
[[Category: Calcium]]
[[Category: Catalytic domain]]
[[Category: Extracellular matrix]]
[[Category: Glycoprotein]]
[[Category: Human gene]]
[[Category: Hydrolase]]
[[Category: Macrophage elastase]]
[[Category: Matrix metalloproteinase]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protein-ligand structure]]
[[Category: Secreted]]
[[Category: Zinc]]
[[Category: Zymogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:33:42 2008''
Retrieved from "https://proteopedia.org/2k2g"