1qa9: Difference between revisions

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{{Seed}}
[[Image:1qa9.png|left|200px]]


<!--
==Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors==
The line below this paragraph, containing "STRUCTURE_1qa9", creates the "Structure Box" on the page.
<StructureSection load='1qa9' size='340' side='right'caption='[[1qa9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qa9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QA9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa9 OCA], [https://pdbe.org/1qa9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qa9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qa9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qa9 ProSAT]</span></td></tr>
{{STRUCTURE_1qa9| PDB=1qa9 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD2_HUMAN CD2_HUMAN] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qa/1qa9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qa9 ConSurf].
<div style="clear:both"></div>


===Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors===
==See Also==
 
*[[CD2|CD2]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10380930}}, adds the Publication Abstract to the page
[[Category: Homo sapiens]]
(as it appears on PubMed at http://www.pubmed.gov), where 10380930 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Kim M]]
{{ABSTRACT_PUBMED_10380930}}
[[Category: Liu J-H]]
 
[[Category: Reinherz EL]]
==About this Structure==
[[Category: Smolyar A]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA9 OCA].
[[Category: Sun ZJ]]
 
[[Category: Tan K]]
==Reference==
[[Category: Wagner G]]
Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors., Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL, Cell. 1999 Jun 11;97(6):791-803. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10380930 10380930]
[[Category: Wang J-H]]
[[Category: Kim, M.]]
[[Category: Liu, J H.]]
[[Category: Reinherz, E L.]]
[[Category: Smolyar, A.]]
[[Category: Sun, Z J.]]
[[Category: Tan, K.]]
[[Category: Wagner, G.]]
[[Category: Wang, J H.]]
[[Category: Cd2]]
[[Category: Cd58]]
[[Category: Cell adhesion]]
[[Category: Ig-like domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:48:09 2008''

Latest revision as of 08:14, 14 February 2024

Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors

1qa9, resolution 3.20Å

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