2a5p: Difference between revisions

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{{Seed}}
[[Image:2a5p.png|left|200px]]


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==Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.==
The line below this paragraph, containing "STRUCTURE_2a5p", creates the "Structure Box" on the page.
<StructureSection load='2a5p' size='340' side='right'caption='[[2a5p]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2a5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5p OCA], [https://pdbe.org/2a5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5p RCSB], [https://www.ebi.ac.uk/pdbsum/2a5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5p ProSAT]</span></td></tr>
{{STRUCTURE_2a5p|  PDB=2a5p  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One recent important example is the guanine-quadruplex (G-quadruplex) structure formed by guanine tracts found in the MYC (or c-myc) promoter region, which regulates the transcription of the MYC oncogene. Stabilization of this G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases the transcriptional level of MYC. Here, we report the first structure of a DNA fragment containing five guanine tracts from this region. An unusual G-quadruplex fold, which was derived from NMR restraints using unambiguous model-independent resonance assignment approaches, involves a core of three stacked guanine tetrads formed by four parallel guanine tracts with all anti guanines and a snapback 3'-end syn guanine. We have determined the structure of the complex formed between this G-quadruplex and TMPyP4. This structural information, combined with details of small-molecule interaction, provides a platform for the design of anticancer drugs targeting multi-guanine-tract sequences that are found in the MYC and other oncogenic promoters, as well as in telomeres.


===Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.===
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.,Phan AT, Kuryavyi V, Gaw HY, Patel DJ Nat Chem Biol. 2005 Aug;1(3):167-73. Epub 2005 Jul 17. PMID:16408022<ref>PMID:16408022</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_16408022}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2a5p" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 16408022 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_16408022}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5P OCA].
[[Category: Large Structures]]
 
[[Category: Gaw HY]]
==Reference==
[[Category: Kuryavyi VV]]
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter., Phan AT, Kuryavyi V, Gaw HY, Patel DJ, Nat Chem Biol. 2005 Aug;1(3):167-73. Epub 2005 Jul 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16408022 16408022]
[[Category: Patel DJ]]
[[Category: Gaw, H Y.]]
[[Category: Phan AT]]
[[Category: Kuryavyi, V V.]]
[[Category: Patel, D J.]]
[[Category: Phan, A T.]]
[[Category: C-myc promoter 3+1 g-tetrad]]
[[Category: Gaag loop]]
[[Category: Gag triad]]
[[Category: Monomeric parallel-stranded quadruplex]]
[[Category: Single nucleotide chain reversal loop]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:01:24 2008''

Latest revision as of 16:31, 13 December 2023

Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.

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