2pno: Difference between revisions

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{{Seed}}
[[Image:2pno.png|left|200px]]


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==Crystal structure of human leukotriene C4 synthase==
The line below this paragraph, containing "STRUCTURE_2pno", creates the "Structure Box" on the page.
<StructureSection load='2pno' size='340' side='right'caption='[[2pno]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pno]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
{{STRUCTURE_2pno| PDB=2pno |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pno OCA], [https://pdbe.org/2pno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pno RCSB], [https://www.ebi.ac.uk/pdbsum/2pno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pno ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
== Function ==
[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pno_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pno ConSurf].
<div style="clear:both"></div>


===Crystal structure of human leukotriene C4 synthase===
==See Also==
 
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_17632548}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17632548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17632548}}
 
==About this Structure==
2PNO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNO OCA].
 
==Reference==
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis., Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M, Nature. 2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17632548 17632548]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ago, H.]]
[[Category: Ago H]]
[[Category: Austen, K F.]]
[[Category: Austen KF]]
[[Category: Irikura, D.]]
[[Category: Irikura D]]
[[Category: Kanaoka, Y.]]
[[Category: Kanaoka Y]]
[[Category: Lam, B K.]]
[[Category: Lam BK]]
[[Category: Miyano, M.]]
[[Category: Miyano M]]
[[Category: Shimamura, T.]]
[[Category: Shimamura T]]
[[Category: Helix bundle]]
[[Category: Homo trimer]]
[[Category: Lyase]]
[[Category: Mapeg]]
[[Category: Membrane protein]]
[[Category: Mgst]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:46:33 2008''

Latest revision as of 13:53, 13 March 2024

Crystal structure of human leukotriene C4 synthase

2pno, resolution 3.30Å

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